Method for identifying compounds for treating aging...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C435S006120, C435S069100, C530S327000, C530S326000

Reexamination Certificate

active

07348155

ABSTRACT:
The invention relates to a method for identifying a compound which modifies the activity of the urotensin II receptor, with genes or gene products which are involved in the structure, formation or breakdown of the extracellular matrix being influenced.

REFERENCES:
patent: WO99/40192 (1999-08-01), None
patent: WO00/75168 (2000-12-01), None
patent: WO 01/14888 (2001-03-01), None
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A. Tzanidis et al., Urotensin II Stimulates Collagen Synthesis By Cardiac Fibroblasts And Hypertrophic Signalling In Cardiomyocytes Via G(alpha)q- and Ras-dependent Pathways, Journ. of American College of Cardiology, vol. 37, No. 2, Feb. 2001, p. 164A.
Fitzgerald et al., Matrix metalloproteinases can facilitate the heparanase-induced promotion of phenotypic chane in vascular smooth muscle cells, Atherosclerosis, vol. 145, No. 1, Jul. 1999, pp. 97-106.
Chen et al., CTGF Expression is Induced by TGF-Beta in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis, Journ. of Molecular and Celluclar Cardiology, vol. 32, No. 10, Oct. 2000, pp. 1805-1819.
Douglas et al., Human Urotension-II, the Most Potent Mammalian Vasconstrictor Identified To Date, as a Therapeutic Target for the Management of Cardiovascular Disease, Trends in Cardiovascular Medicine, vol. 10, No. 6, Aug. 2000, pp. 229-237.

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