Method for identifying autoimmune disease, method for...

Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease

Reexamination Certificate

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C435S007100, C435S007900, C435S069300, C435S069400, C435S975000, C436S503000, C436S524000, C436S528000, C436S534000, C436S536000, C436S811000, C530S396000, C530S403000, C530S806000, C530S845000

Reexamination Certificate

active

06919210

ABSTRACT:
A method for judging an autoimmune disease by detecting the existence of an anti-Reg protein autoantibody in a specimen; and a method for judging insulin-dependent or non-insulin-dependent diabetes mellitus.A method for detecting an anti-Reg protein autoantibody by bringing into a specimen into contact with an antigen component and detecting the formation of an immune complex.A reagent for diagnosing autoimmune disease which contain an antigen component capable of binding specifically to the anti-Reg protein autoantibody; and a reagent for diagnosing insulin-dependent or non-insulin-dependent diabetes mellitus.

REFERENCES:
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patent: 1-137994 (1989-05-01), None
Kimio Terazono, et al., “A Novel Gene Activated in Regenerating Islets,” The Journal of Biological Chemistry, vol. 283, No. 5, pp. 2111-2114 1988.
Jacqueline Carrère, et al., “Human pancreatic reg protein Immunoenzymatic assay and molecular form in serum,” Clinica Chimica Acta, vol. 273, pp. 185-194, 1998.
David J. Gross, et al., “Amelioration of Diabetes in Nonobese Diabetic Mice with Advanced Disease by Linomide-Induced Immunoregulation Combined with Reg Protein Treatment,” Endocrinology, vol. 139, No. 5, pp. 2369-2374, 1998.
C. Ishi, et al. “Appearance of a Regenerating (Reg) Gene Protein in Pancreatic Islets of Remission BB/WOR/TKY Rats”, Endocrine Journal, vol. 40, No. 1993, pp. 269-273.
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H. Okamoto, “Autoantibody Against Reg I Protein in Nidm Patients”, Diabetes, vol. 48 (Supplement1), 1999, p. A444.
H. Okamoto, “Igaku no Ayumi, Bessatsu, Jun.”, 1999, pp. 153-157 (with a partial translation), Translation Only Considered.
Itoh, “Isolation and Characterization of Human reg Protein Produced inSaccharomyces cerevisiae, ”FEBS Letters, vol. 272, No. 1,2, pp. 85-88, Oct. 1990.
Supplementary European Search Report completed on Nov. 10, 2004, and issued to a related foreign application.

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