Method for identifying auto-immunoreactive substances from a sub

Details Method for identifying auto-immunoreactive substances from a sub Method for identifying auto-immunoreactive substances from a sub

1995-06-07

1997-12-16

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 71, 435 723, C12Q 168, C12Q 170, G01N 3353, G01N 33574

Patent

active

056983964

ABSTRACT:
The invention describes methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of the host cells are screened with a sample, treated to remove interfering binding partners. The treatment involves contact of the sample to lysates of untransfected host cells, and host cells transfected or transformed with the same vector used to make the cDNA library. Also a part of the invention are antigens and cDNA identified using the methodology.

REFERENCES:
patent: 5571710 (1996-11-01), Barnett et al.
patent: 5583024 (1996-12-01), McElroy et al.
patent: 5583046 (1996-12-01), Valenta et al.
patent: 5585258 (1996-12-01), Houghton et al.
patent: 5585464 (1996-12-01), Prakash
patent: 5587304 (1996-12-01), Barre et al.
Breiteneder et al. (1989) EMBO J. 8:1935-38.
de Wet et al. (1984) DNA 3:437-447.

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