Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Reexamination Certificate
2006-01-24
2006-01-24
Foley, Shanon (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
C435S238000, C568S021000, C568S025000, C548S548000
Reexamination Certificate
active
06989263
ABSTRACT:
The present invention provides several classes of compounds which can be used to inactivate retroviruses, such as HIV-1, by attacking the CCHC zinc fingers of the viral nucleocapsid protein and ejecting the zinc therefrom. In addition, kits for identifying compounds that can react with CCHC zinc fingers of the nucleocapsid proteins of a large number of different retroviruses have also been developed. The kits of the present invention describe a set of specific tests and reagents that can be used to screen and identify compounds based on their ability to react with and disrupt retroviral zinc fingers in the viral NC proteins and, in turn, inactivate the retrovirus of interest.
REFERENCES:
patent: 6001555 (1999-12-01), Henderson et al.
patent: WO 92/15329 (1992-09-01), None
patent: WO 93/15730 (1993-08-01), None
patent: WO 94/19321 (1994-09-01), None
Rice et al. Nature. Feb., 1993, 361: 473-475.
Ryser et al. PNAS. May, 1994. 91: 4559-4563.
HCAPLUS search term printout of WO 94/19321, Williams et al. Sep. 1, 1994. AN: 1994: 655644.
Arthur Larry O.
Henderson Louis E.
Rice William G.
Foley Shanon
The United States of America as represented by the Secretary of
Townsend & Townsend & Crew LLP
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