Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-12-06
1995-04-11
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 435 792, 436506, 436813, 436 63, 436 64, 530350, 530413, 530416, 530417, G01N 33574, C07K 300, C07K 1300
Patent
active
054057493
ABSTRACT:
A method of screening for cancer-associated retinopathy including the steps of acquiring a purified aliquot of 26 kDa protein, and, utilizing this protein, or peptides derived therefrom, performing a patient-serum assay to identify in a sample of a patient's serum the presence of autoantibodies to the 26 kDa protein autoantigen.
REFERENCES:
Dizhoor, A. M., et al, Science, vol. 251, 915-918, 22 Feb. 1991.
Kutuzov, M. A., et al, FEBS Letters, vol. 293, 21-24, Nov. 1991.
Dizhoor, A. M. et al. Biochem. Biophys. Res. Commun., vol. 162, 544-547, 1989.
Brain, L., and F. H. Norris: The Remote Effects of Cancer on the Nervous System. Grune & Stratton, New York, 1965.
Brain L., and M. Wilkinson: Subacute cerebellar degeneration associated with neoplasms. Brain. 88:465-478, 1965.
Brain W. R., P. M. Daniel, and J. G. Greenfield: Subacute cortical cerebellar degeneration and its relation to carcinoma. J. Neurol. Neurosurg. Psychiatr. 14:59-75, 1951.
Croft, P. B., and M. Wilkinson: Carcinomatous neuromyopathy: its incidence in patients with carcinoma of the lung and carcinoma of the breast. Lancet. i:184-188. 1963.
Denny-Brown, D.: Primary sensory neuropathy with muscular changes associated with carcinoma. J. Neurol. Neurosurg. Psychiatr. 11:73-87, 1948.
Hawley, R. J., M. H. Cohen, N. Saini, and V. W. Armbrustmacher: The carcinomatous neuromyopathy of oat cell lung cancer. Ann. Neurol. 7:65-72, 1980.
Henson, R. A., and H. Urich: Cancer and the Nervous System: The Neurological Manifestations of Systemic Malignant Disease. Blackwell Scientific, Oxford. 346-367, 1982.
Bunn, P. A., and J. D. Minna Paraneoplastic syndromes. In Cancer: Principles and Practice of Oncology. V. T. Devita, S. A. Rosenberg, and S. Hellman, editors, J. B. Lippincott & Co., Philadelphia, 1797-1842, 1982.
Norris, F.: The remote effects of cancer on the nervous system. Z. Neurol. 201:201-207, 1972.
Sawyer, R. A., J. B. Selhorst, L. E. Zimmerman, and W. F. Hoyt: Blindness caused by photoreceptor degeneration as a remote effect of cancer. Am. J. Ophthalmol. 81:606-613, 1976.
Schold, S. C., E. S. Cho, and M. Somasundaram: Subacute motor neuronapathy: A remote effect of lymphoma. Ann. Neurol. 5:271-287, 1979.
Anderson, N. E., M. K. Rosenblum, and J. B. Posner: Paraneoplastic cerebellar degeneration: clinical-immunologic correlations. Ann. Neurol. 24:559-567, 1988.
Keltner, J. L., A. M. Roth, and R. S. Chang: Photoreceptor degeneration: possible autoimmune disorder. Arch. Ophthalmol. 101:564-569, 1983.
Kornguth, S. E., R. Klein, R. Appen, and J. Choate: Occurrence of antiretinal ganglion cell antibodies in patients with small cell carcinoma of the lung. Cancer. 50:1289-1293, 1982.
DeAizpurua, H. J., E. H. Lambert, G. E. Greismann, B. M. Olivera, and V. A. Lennon: Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndromes by autoantibodies, .omega.-conotoxin and adenosine. Cancer Res. 48:4719-4724, 1988.
Kim, Y. I., and E. Neher: IgG from pateints with Lambert-Eaton syndrome blocks voltage-dependent calcium channels. Science (Wash. D.C.). 239:405-408. 1988.
Newsom-Davis, J.: Lambert-Eaton myasthenic syndrome. Sem. Immunopathol. 8:129-140, 1985.
Furneaux, H. F., L. Reich, and J. B. Posner: Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology. 40:1085-1091, 1990.
Greenlee, J. E., and H. I. Lipton: Anti-cerebellar antibodies in serum and cerebrospinal fluid of a patient with oat cell carcinoma of the lung and paraneoplastic cerebellar degeneration. Ann. Neurol. 19:82-85, 1986.
Buchanan, T. A. S., T. A. Gardiner, and D. B. Archer: An ultrastructural study of retinal photoreceptor degeneration associated with bronchial carcinoma. Am. J. Ophthalmol. 97:277-287, 1984.
Grunwald, G. B., M. A. Simmonds, R. Klein, and J. E. Kornguth: Autoimmune basis for visual paraneoplastic syndrome in patients with small cell lung carcinoma. Lancet. i:658-661, 1985.
Thirkill, C. E., P. Fitzgerald, R. C. Sergott, A. M. Roth, N. K. Tyler, and J. L. Keltner: Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retino, optic-nerve and cancer cells. N. Engl. J. Med. 321:1589-1594, 1989.
Thirkill, C. E., A. M. Roth, and J. L. Keltner: Cancer-associated retinopathy. Arch. Ophthalmol. 105:372-375, 1987.
Tso, M. O. M.: Experiments on visual cells by nature and man: in search of treatment for photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 30:2430-2460, 1989.
Galbraith, G. M. P., D. Emerson, H. H. Fudenberg, C. J. Gibbs, and D. C. Gajdusek: Antibodies to neurofilament protein in retinitis pigmentosa. J. Clin. Invest. 78:865-869, 1986.
Gurne, D., D. P. Edward, N. Mangini, and M. O. M. Tso: Antiretinal antibodies in serum of patients with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 30:366a, 1989 Abstract only.
Papermaster, D. S.: Preparation of retinal rod outer segments. Methods Enzymol. 81:48-52, 1982.
Polans, A. S., J. Hermolin, and M. D. Bownds: Light-induced dephosphorylation of two proteins in frog rod outer segments. Influence of cyclic nucleotides and calcium. J. Gen. Physiol. 74:595-613, 1979.
Polans, A. S., and M. D. Burton: Sialoglycoproteins of the frog rod outer segment plasma membrane. Invest. Ophthalmol. Vis. Sci. 29:1523-1532, 1988.
Huang, J., and H. Matthews: Application of sodium dodecylsulfate-gel electrophoresis to low molecular weight polypeptides. Anal. Biochem. 188:114-117, 1990.
Schagger, H., and G. von Jagow: Tricine-sodium dodecylsulfatepolyacrylamide gel electrophoresis for the separation of proteins in the range of 1-100kDa. Anal. Biochem. 166:368-379, 1987.
Bradford, M.: A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of dye-binding. Anal. Bio-chem. 72:248-254, 1976.
Burton, M. D., L. T. Onstott, and A. S. Polans: The use of gold reagents to quantitate antibodies eluted from nitrocellulose blots: application to EM immunocytochemistry. Anal. Biochem. 183:225-230, 1989.
Wilden, U., and H. Kuhn: Light-dependent phosphorylation of rhodopsin number of phosphorylation sites. Biochemistry. 21:3014-3022, 1982.
Crestfield, A. M., S. Moore, and W. J. Stein: The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins. J. Biol. Chem. 238:662-627, 1963.
Lai, C. H.: Studies on the structure of rabbit muscle aldolase. I. Cleavage with cyanogen bromide: an approach on the determination of the total primary structure. Arch. Biochem. Biophys. 128:202-211, 1968.
Matsudaira, P.: Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262:10035-10038, 1987.
Crabb, J. W., L. G. Armes, S. A. Carr, C. M. Johnson, G. D. Roberts, R. S. Bordoli, and W. L. McKeehan: Complete primary structure of prostatropin, a prostate epithelial cell growth factor. Biochemistry. 25:4988-4993, 1986.
West, K. W., and J. W. Crabb: Current Research in Protein Chemistry. J. J. Villafranca, editor. 37-48, 1990.
Crabb, J. W., C. M. Johnson, S. A. Carr, L. G. Armes, and J. C. Saari: The complete primary structure of the cellular retinaldehyde-binding protein from bovine retina. J. Biol. Chem. 263:18678-18687, 1988.
Polans, Arthur S., Janina Buczylko, John Carbb, and Krzysztof Palczewski: A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J. Cell Biol. 112:981-989, 1991.
Palczewski Krzysztof
Polans Arthur S.
LandOfFree
Method for identifying and purifying a cancer associated retinop does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for identifying and purifying a cancer associated retinop, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for identifying and purifying a cancer associated retinop will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1537767