Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2007-06-12
2007-06-12
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S013000, C800S018000
Reexamination Certificate
active
10124334
ABSTRACT:
Provided is a method for determining whether an agent is an agonist of the neuron-specific calcium sensor-1 (NCS-1), for consideration of an agonist of NCS-1 as a drug candidate for therapy of a behavioral disorder or for improving learning and/or memory of a subject, said method comprising the steps of:(a) contacting a cell, tissue or non-human animal with an agent to be screened under conditions to permit neuron-specific calcium sensor-1 (NCS-1) activity; and(b) determining NCS-1 activity of said treated cell, tissue or non-human animal, wherein an increase in NCS-1 activity compared with a corresponding control cell, tissue or animal is indicative of an agent which is an agonist of NCS-1.
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Falk Anne-Marie
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
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