Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2005-09-23
2010-12-07
Goddard, Laura B (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
Reexamination Certificate
active
07846683
ABSTRACT:
The present invention relates to a method for identifying an agent. for modulating cell growth or survival. The method involves the identification of an agent which modulates the net ratio of nuclear-localized versus cytosolic-localized H11 kinase or mutant H11 kinase in a cell. A method for diagnosing a cancer associated with H11 kinase or Akt activation in a subject is also provided.
REFERENCES:
patent: 5962262 (1999-10-01), Hillman et al.
patent: WO0111012 (2001-02-01), None
Gober et al (J Biological Chemistry, Epub Jun. 26, 2003, vol. 278, p. 37600-37609).
Gober et al, Journal of Biological Chemistry, 2003, 278:37600-37609, IDS.
Li et al, Oncogene, 2007, 26:3521-3531.
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Bowie et al (Science, 1990, 247:1306-1310).
Gober et al (Journal of Biochemistry, 2003, 278:37600-37609).
Li et al (Oncogene, 2007, 26:3521-3531).
Cantley, Lewis C., “The Phosphoinositide 3-Kinase Pathway”, Science 2002 296:1655-1657.
Depre et al., “Gene program for cardiac cell survival induced by transient ischemia in conscious pigs”, Proc. Natl. Acad. Sci. USA 2001 98(16):9336-9341.
Depre et al., “Program of Cell Survival Underlying Human and Experimental Hibernating Myocardium”, Circ Res 2004 95:433-440.
Depre et al., “Glucose for the Heart”, Circulation 1999 99:578-588.
Depre et al., “H11 Kinase Is a Novel Mediator of Myocardial Hypertrophy In Vivo”, Circ Res. 2002 91:1007-1014.
Gober et al., “Forced Expression of the H11 Heat Shock Protein Can Be Regulated by DNA Methylation and Trigger Apoptosis in Human Cells”, J. Biol. Chem. 2003 278(39):37600-37609.
Hase et al., “H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes”, Biochem. J. 2005 388:475-483.
Hay and Sonenberg 2004 Genes Dev. 18:1926-1945.
Kappe et al., “Characterization of two novel human small heat shock proteins:protein kinase-related HspB8 and testis-specific HspB9”, Biochimica et Biophysica Acta 1520 2001 1-6.
Knowlton, A.A., “Mutation of Amino Acids 246-251 Alters Nuclear Accumulation of Human Heat Shock Protein (HSP) 72 with Stress, But Does Not Reduce Viability”, J Mel Cell Cardiol 1999 31:523-532.
Russell III et al., “AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury”, The Journal of Clinical Investigation 2004 114(4):495-503.
Smith et al., “A Novel Human Gene Similar to the Protein Kinase (PK) Coding Domain of the Large Subunit of Herpes Simplex Virus Type 2 Ribonucleotide (ICP10) Codes for a Serine-Threonine PK and Is Expressed in Melanoma Cells”, J. Biol. Chem. 2000 275(33):25690-25699.
Wange et al., “Increased expression of H11 kinase stimulates glycogen synthesis in the heart”, Mol Cell Biochem 2004 265:71-78.
Yu et al., Expression analysis and chromosomes location of a novel gene (H11) associated with the growth of human melanoma cells, International Journal of Oncology 2001 18:905-911.
Depre Christopher
Vatner Stephen F.
Goddard Laura B
University of Medicine and Dentistry of New Jersey
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