Method for identification of t-cell epitopes and use for...

Details Method for identification of t-cell epitopes and use for... Method for identification of t-cell epitopes and use for...

2002-02-18

2008-09-30

Borin, Michael (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C424S195110, C424S185100, C424S193100

Reexamination Certificate

active

07430476

ABSTRACT:
This invention relates to a novel approach for identification of T-cell epitopes, that give rise to an immune reaction in a living host. By means of this novel method biological compounds can be generated which have a no or at least a reduced immunogenicity when exposed to the immune system of a given species and compared with the relevant non-modified entity. Thus the invention relates also to novel biological molecules, especially proteins and antibodies, obtained by the method according to the invention.

REFERENCES:
patent: 98/52976 (1998-11-01), None
Grandi et al Trends in Biotechnology, 19 (5), 181488, 2001.
Doychinova et al. Immuniology and Cell Biology, 80, 270-279, 2002.
Boehncke et al. J. Immunol, vol. 150, 331-341, No. 2, 1993.
Gohlke et al. J. Mol. Biol., 2000, 295; pt 2, pp. 337-356).

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