Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-09-11
2007-09-11
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C530S350000
Reexamination Certificate
active
10491643
ABSTRACT:
The invention relates to a method for identification of a compound which modulates pre-adipocyte differentiation comprising testing whether the compound modulates the activity and/or amount of O/E-1 and/or O/E-2 and/or O/E-3. The invention also relates to use of a compound able to modulate the activity or amount of O/E-1 and/or O/E-2 and/or O/E-3 in preparation of a medicament for the treatment or prevention of atherosclerosis, dyslipidemia, IRS, and type 2 diabetes.
REFERENCES:
patent: 1158044 (2000-02-01), None
patent: WO-00/44882 (2000-08-01), None
patent: WO-00/46348 (2000-08-01), None
patent: WO-01/64238 (2001-09-01), None
Dowell et al., “Olf-1/Early B Cell Factor is a Regulator ofglut4Gene Expression in 3T3-L1 Adipocytes,” The Journal of Biological Chemistry 277(3):1712-1718 (2002).
Milatovich et al., “Gene for a Tissue-specific Transcriptional Activator (EBF or OLF-1), Expressed iin Early B Lymphocytes, Adipocytes, and Olfactor Neurons, is Located on Human Chromosome 5, Band q34, and Proximal Mouse Chromosome 11,” Mammalian Genome 5:211-215 (1994).
Hagman et al., “EBF Contains a Novel Zinc Coordination Mofit and Multiple Dimerization and Transcriptional Activation Domains,” The Embo Journal 14(12):2907-2916 (1995).
Akerbald Peter
Sigvardsson Mikael
AstraZeneca AB
Ketter James
LandOfFree
Method for identification of modulators of pre-adipocyte... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for identification of modulators of pre-adipocyte..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for identification of modulators of pre-adipocyte... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3736817