Method for identification of high affinity DNA ligands of HIV-1

Details Method for identification of high affinity DNA ligands of HIV-1 Method for identification of high affinity DNA ligands of HIV-1

1994-05-06

1996-04-02

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, C12Q 168, C12P 1934

Patent

active

055039782

ABSTRACT:
Methods are described for the identification and preparation of DNA ligands to the HIV-1 reverse transcriptase protein. The invention encompasses specific ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method including ssDNA ligands that inhibit the activity of HIV-1 reverse transcriptase.

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