Method for identification and/or diagnosis of REM sleep loss...

Chemistry: analytical and immunological testing – Peptide – protein or amino acid

Reexamination Certificate

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Reexamination Certificate

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07125724

ABSTRACT:
The present invention relates to a method for identification and/or diagnosis of REM sleep loss. More particularly, the present invention relates to a method for identification and/or diagnosis of REM sleep loss from blood samples.

REFERENCES:
patent: 28 01 918 (1979-07-01), None
patent: 02 166202 (1990-06-01), None
patent: 04 350107 (1992-12-01), None
patent: 2004 124155 (2004-04-01), None
patent: 01/17671 (2001-03-01), None
patent: 03/080275 (2003-10-01), None
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Durand et al. “Protein Glycosylation and Diseases: Blood and Urinary Oligosaccharides as Markers for Diagnosis and Therapeutic Monitoring,” Clinical Chemistry 46:6 795-805 (2000).
Mallick et al. “Norephinephrine-Stimulated Increase in Na+, K+-ATPase Activity in the Rat Brain is Mediated Through alpha1A-Adrenoceptor Possibly by Dephosphorylation of the Enzyme,” J. Neurochem. 74, 1574-1578 (2000).
Takahashi et al. “Inhibition of tumor necrosis factor in teh brain suppresses rabit sleep,” Pflugers Arch. 431(2): 155-60 (1995) abstract.
Tobler et al. “Sleep and Sleep Regulation in Normal and Prion Protein Deficient Mice,” The Journal of Neuroscience, 17(5): 1869-1879(1997).
Deboer et al. “Tumor Necrosis Factor (TNF) Ligand and TNF Receptor Deficiency Affects Sleep and the Sleep EEG,” J. Neurophysiol., 88: 839-846 (2002).
Patent Abstracts of Japan of JP 04-350107 dated Dec. 4, 1992.
Patent Abstracts of Japan of JP 02-166202 dated Jun. 26, 1990.
Patent Abstracts of Japan of JP 2004-124155 dated Apr. 22, 2004.

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