Method for hypermutagenesis of nucleotides

Details Method for hypermutagenesis of nucleotides Method for hypermutagenesis of nucleotides

1995-05-19

1998-12-01

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 912, 435 9121, 435 913, 435 9151, 435 691, C12P 1934

Patent

active

058437304

ABSTRACT:
The present invention features a method for introducing hypermutations into a target DNA or RNA sequence of interest, characterized in that said method comprises the steps of:

REFERENCES:
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Jean-Pierre Vartanian et al., G.fwdarw.A hypermutation of the human inmmunodeficency virus type 1 genome: Evidence for dCTP pool imbalance during reverse transcription, Proc. Natl. Acad. Sci. vol. 91, No. 8, Apr. 12, 1994, pp. 3092-3096.
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Gerald F. Joyce, "Amplification, mutation and selection of catalytic RNA", Gene, vol. 82, No, 1, Oct. 1989, pp. 83-87.
Jean-Pierre Vartanian et al., "Selection, Recombination, and G.fwdarw.A Hypermutation of Human Immunodeficiency Virus Type 1 Genomes", J. Virol., vol. 65, No. 4, Apr. 1994, pp. 1779-1788.
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