Method for HLA DP typing

Details Method for HLA DP typing Method for HLA DP typing

1989-05-04

1994-05-10

Fleisher, Mindy B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2433, 435 6, 935 77, 935 78, C07H 2104, C12Q 168, C12N 1500

Patent

active

053108930

ABSTRACT:
A process for determining the genotype of an individual with respect to the alleles at the HLA DP locus involves obtaining a sample of nucleic acid from the individual, and hybridizing the nucleic acids with a panel of probes specific for variant segments of DPalpha and DPbeta genes. Because the variation between DPbeta alleles is highly dispersed throughout the second exon of the DPbeta gene, the discovery of many different DPbeta alleles makes the process far more discriminating and informative than cellular, RFLP, or serological methods. The process can also be carried out on amplified nucleic acid produced by the polymerase chain reaction using primers specific for the second exon of the DPalpha and DPbeta genes. HLA DP DNA typing methods are useful in the prevention of graft rejection and host versus graft disease, in determining susceptibility to autoimmune diseases, in providing evidence concerning the derivation from an individual of forensic samples, and in paternity testing.

REFERENCES:
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4582788 (1986-04-01), Erlich
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4889818 (1989-12-01), Gelfand et al.
patent: 5110920 (1992-05-01), Erlich
Saiki et al, Nature, vol. 324, pp. 163-166, Nov. 13, 1986.
Kelly et al, Nucleic Acids Res. vol. 13, No. 5, pp. 1607-1621 (1985).
Scharf et al, Science, vol. 233, pp. 1076-1078 (1986).
Giles et al, 1985, Adv. Immunol. 37 (ed. Dixon, Academic Press).
HLA Class II Antigens, Solheim et al. eds., Springer-Verlag, pp. 32-48 (1986).
Lawrence et al, Nucleic Acids Res., vol. 13, No. 20, pp. 7515-7528 (1985).
Gustafsson et al, J. Biol. Chem., vol. 262, No. 18, pp. 8778-8786 (1987).
Compagnone-Post et al, Genomics, 2, pp. 8-13 (1988).
Choi et al, Science, vol. 211, Jul. 15, 1983, pp. 283-286.
Beaucage et al., 1981, Tetr. Ltrs. 22(20):1859-1862.
Urdea et al., 1988, Nuc. Acids Res. 16(11):4937-4956.
Murasugi and Wallace, 1984, DNA 3(3):269-277.
Wank et al., 1978, Immunogenetics 6:107-115.
Shaw et al., 1980, J. Exp. Med. 152:565-580.
Mawas et al., 1980, Tissue Antigens 15:458-466.
Kavathas et al., Oct. 29, 1981, Nature 293:747-749.
Shaw et al., 1982, J. Exp. Med. 156:731-743.
Wake et al., Nov. 25, 1982, Nature 300:372-374.
Bohme et al., Jan. 6, 1983, Nature 301:82-84.
Roux-Dosseto et al., Oct. 1983, Proc. Natl. Acad. Sci. USA 80:6036-6040.
Gustafsson et al., May 3, 1984, Nature 309:76-78.
Kappes et al., 1984, EMBO J. 3(12):2985-2993.
Servenius et al., 1984 EMBO J. 3(13):3209-3214.
Spielman et al., Jun. 1984, Proc. Natl. Acad. Sci. USA 81:3461-3465.
Gorski et al., Jul. 1984, Proc. Natl. Acad. Sci. USA 81:3934-3938.
Giles and Capra, 1985, Adv. Immunol. 37:1-68 (ed. Dixon, Academic Press).
Kelly and Trowsdale, 1985, Nuc. Acids Res. 13(5):1607-1621.
Trowsdale et al., Jul. 1985, Immunol. Rev. 85:5-43.
Ando et al., 1986, Hum. Immunol. 17:355-67.
Odum et al., 1986, Tissue Antigens 28:245-250.
Hoffman et al., Sep. 1986, Arthritis and Rheumatism 29(9):1057-62.
Odum et al., 1987, Tissue Antigens 29:101-109.
Lotteau et al., 1987, Immunogenetics 25:403-7.
Hyldig-Nielsen et al., Mar. 1987, Proc. Natl. Acad. Sci. USA 84:1644-1648.
Bodmer et al., Jul. 1987, Proc. Natl. Acad. Sci. USA 84:4596-4600.
Amar et al., Mar. 15, 1987, J. Immunol 138(6):1947-53.
Niven et al., Oct. 3, 1987, Lancet, p. 805.
Kappes and Strominger, 1988, Ann. Rev. Biochem. 57:991-1028.
Odum et al., 1988, Tiss. Ant. 31:235-237.
Maeda et al., 1988, Hum. Immunol. 21(4):239-248.
Howell et al., Jan. 1988, Proc. Natl. Acad. Sci. USA 85:222-226.
Scharf et al., May 1988, Proc. Natl. Acad. Sci. USA 85:3504-3508.
Maeda et al., Jul. 1988, Chem. Abst. 109(1):175, 1766k.
Bugawan et al., Aug. 1988, Bio/Technology 6:943-947.
Horn et al., Aug. 1988, Proc. Natl. Acad. Sci. USA 85:6012-6016.
Begovich et al., 1988, Hum. Immunol. 23(2):81.
Scharf et al., 1988, Hum. Immunol. 23(2):143.
Bugawan et al., Dec. 1, 1988, J. Immunol 141(12):4024-4030.
Erlich, Jan. 30, 1989, Dept. HHS Grant App.
Bugawan et al. Jun. 8, 1989, Nature 339:470-473.
Angelini et al., 1989, Hum. Immunol. 26:169-177.
Begovich et al., Dec. 1989, Proc. Natl. Acad. Sci. USA 86:9489-9493.
Lee et al., 1989, Immunogenet. 29:346-349.
Scharf et al., Sep. 5, 1986, Science 233:1076-78.
Saiki et al., Nov. 13, 1986, Nature 324(6093):163-166.

Affiliated with

Also associated with

Rating

Method for HLA DP typing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for HLA DP typing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for HLA DP typing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2413193