Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Free from infectious agents
Reexamination Certificate
2005-05-17
2005-05-17
Saunders, David (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Free from infectious agents
C424S177100, C530S390100, C530S390500, C530S414000, C530S416000, C530S419000
Reexamination Certificate
active
06893639
ABSTRACT:
The method for immune serum globulin purification relates to the purification of immune globulins from blood plasma with a high degree of efficiency and a high rate of recovery. The immune globulin source is Cohn's fraction I+II+III or II+III prepared from plasma or plasma intermediates by precipitation of the paste at pH 5.7 to 5.8 in the presence of 20% ethanol and 80% purified water. A glycine extraction is followed by an anion exchange chromatography column step to achieve a significantly high yield and high purity of the concentrated protein.
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K. Tanaka, E. Sawatani, G.A. Dias, E.M. Shigueoka, T.C.X.B. Campos, H.C. Nakao and F. Arashiro, “High Quality Human Immunoglobulin G Purified from Cohn Fractions by Liquid Chromatography.” Brazilian Journal of Medical and Biological Research, Jan. 2000, vol. 33, No. 1, pp. 27-30, Sao Paulo, SP, Brasil.
Levy Joshua
Rothstein Fred
Shimiaei Bahman
Hemacare Corporation
Saunders David
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