Method for high yield and large scale extraction of paclitaxel f

Details Method for high yield and large scale extraction of paclitaxel f Method for high yield and large scale extraction of paclitaxel f

1998-12-30

2000-10-24

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

061369896

ABSTRACT:
A method of isolating paclitaxel from pactitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueous supernatant and a precipitate, wherein the precipitate contains at least 3-times higher paclitaxel content than the paclitaxel extract. The acetone/water precipitation step provides a high yield of highly pure paclitaxel that is suitable for industrial scale isolation using conventional normal-phase silica chromatography steps, and the preparation of pharmaceutical compositions containing paclitaxel.

REFERENCES:
patent: 5279949 (1994-01-01), Nair
patent: 5281727 (1994-01-01), Carver et al.
patent: 5380916 (1995-01-01), Rao
patent: 5393895 (1995-02-01), Gaullier et al.
patent: 5393896 (1995-02-01), Margraff
patent: 5440055 (1995-08-01), Castor
patent: 5445809 (1995-08-01), Strobel et al.
patent: 5451392 (1995-09-01), Strobel et al.
patent: 5453521 (1995-09-01), Gaullier et al.
patent: 5466455 (1995-11-01), Huffstutler, Jr. et al.
patent: 5475120 (1995-12-01), Rao
patent: 5478736 (1995-12-01), Nair
patent: 5480639 (1996-01-01), ElSohly et al.
patent: 5549830 (1996-08-01), Carver et al.
patent: 5561055 (1996-10-01), Page et al.
patent: 5580899 (1996-12-01), Mayhew et al.
patent: 5618538 (1997-04-01), ElSohly et al.
patent: 5620875 (1997-04-01), Hoffman et al.
patent: 5642587 (1997-07-01), Janes et al.
patent: 5654448 (1997-08-01), Pandey et al.
patent: 5670673 (1997-09-01), Rao
patent: 5723635 (1998-03-01), Durand et al.
patent: 5736366 (1998-04-01), Margraff
patent: 5744333 (1998-04-01), Cociancich et al.
Chen and Kingston, "Isolation And Structure Elucidation Of New Taxoids From Taxus Brevifolia," Journal of Natural Products 57(7):1017-1021, 1994.
Huang et al., "New Taxanes From Taxus Brevifolia, 2.sup.1," Journal of Natural Products 49(4):665-669, 1986.
Kingston et al., "Modified Taxols, 7.sup.1 . A Method For The Separation Of Taxol And Cephalomannine," Journal of Natural Products 55(2):259-261, 1992.
Rao, "Taxol and Related Taxanes. I. Taxanes of Taxus brevifolia Bark," Pharmaceutical Research 10(4):521-524, 1993.
Rao et al., "A New Large-Scale Process for Taxol and Related Taxanes form Taxus brevifolia," Pharmaceutical Research 12(7):1003-1010, 1995.

Affiliated with

Also associated with

Rating

Method for high yield and large scale extraction of paclitaxel f does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for high yield and large scale extraction of paclitaxel f, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for high yield and large scale extraction of paclitaxel f will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1965419