Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1998-09-21
2000-05-23
Witz, Jean C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C12P 744
Patent
active
060664800
ABSTRACT:
This invention provides a low-cost method of producing .alpha.,.omega.-alkanedicarboxylic acids. Particular bioconversion conditions result in highly efficient conversion of fatty acid, fatty acid ester, or alkane substrates to diacids. Candida tropicalis AR40 or similar yeast strains are grown in a medium containing a carbon source and a nitrogen source at a temperature of 31.degree. C. to 38.degree. C., while additional carbon source is continuously added, until maximum cell growth is attained. Within 0-3 hours of this point, substrate is added to the culture to initiate conversion. An .alpha.,.omega.-alkanedicarboxylic acid made according to this method is also provided.
REFERENCES:
patent: 5254466 (1993-10-01), Picataggio et al.
patent: 5620878 (1997-04-01), Picataggio et al.
"Microbial Production of Long-Chain Dicarboxylic Acids from n-Alkanes", Agricultural and Biologiccal Chemistry, vol. 35, No. 13, Jan. 1, 1971 pp. 2033-2042.
"Antifungal Properties of Alpha, Omega-Alkanedicarboxylic acids and Their Dimethyl Esters", Can J. Microbiol., vol. 22, 1976, pp. 1198-1201.
Mobley David Paul
Shank Gary Keith
General Electric Company
Johnson Noreen C.
Stoner Douglas E.
Witz Jean C.
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