Method for healing compromised tissues using pyrimidine derivati

Details Method for healing compromised tissues using pyrimidine derivati Method for healing compromised tissues using pyrimidine derivati

1996-05-16

1999-11-02

Richter, Johann

Drug, bio-affecting and body treating compositions

Lymphokine

514255, 514258, 5142342, 5142285, 530300, 530350, A61K 3800

Patent

active

059765232

ABSTRACT:
The present invention provides a method for the screening of a wound-healing agent, which comprises determining a substance to be active as a wound-healing agent on the basis of potentiation or modification of biological activities of a growth and/or differentiation factor, a growth hormone or a cytokine. This invention also provides a wound-healing method, which comprises as an active ingredient a compound of the following formula (1) or formula (2) found to be active by the screening method. ##STR1##

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Dijke, "Growth Factors for Wound Healing" Biothelnology., v.7, pp. 793-798, 1989.
Awaya, "Neurotropic Pyrimidine Heterocyclic Compounds" Biol. Pharm. Bull. v. 16, No. 3, pp. 248-253, 1993.
Yasuhara, "Neurotropic Compound MS-818 promotes Angiogenesis induced by bFGF." Int. J. Clin. Pharm. Res., v. 15, No. (5/6) pp. 167-174, 1995.
Burgess, Embase ABS #89173023 (1989).
Barnes, Biosis ABS #89: 113709, 1988.
Fujitsuka et al., "Muscle Regeneration after Surgical Intervention and Acceleratory Healing by MS-818." Neuroscience Research Supplement 0 (18), 1993.
Int. J. Clin. Pharm. Res. XV (5/6) 167-174 (1995), The Neurotrophic Pyrimidine Heterocyclic Compound MS-818 Promotes the Angiogenesis Induced by Basic FGF, S. Yasuhara, et al.

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