Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1988-07-22
1990-07-10
Richman, Barry S.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 1, 435240241, 435240243, C12N 500, A01N 100
Patent
active
049408534
ABSTRACT:
An apparatus and method for growing tissue specimens in vitro wherein the apparatus includes an expandable membrane for receiving a tissue specimen thereon, a mechanism for expanding the membrane and the tissue specimen, and a controller for controlling the expanding mechanism. The controller is operative in accordance with the method for applying an activity pattern to the membrane and a tissue specimen thereon which includes simultaneous continuous stretch activity and repetitive stretch and release activity. The continuous stretch activity and the repetitive stretch and release activity simulate the types of activity to which cells are exposed in vivo due to growth and movement, respectively, and they cause the cells of tissue specimens grown in the apparatus in accordance with the method to develop as three-dimensional structures similar to those grown in vivo.
REFERENCES:
Program and Abstracts of the 38th Annual Meeting of the Tissue Culture Association, Washington, D.C., May 27-31, 1987.
D. Bray, Developmental Biology 102, pp. 379-389, "Axonal Growth in Response to Experimentally Applied Mechanical Tension".
H. Vandenbaugh, Developmental Biology 93, pp. 438-443, "Dynamic Mechanical Orientation of Skeletal Myofibers in Vitro".
Klein-Nulend et al., The Journal of Biological Chemistry, "Influence of Intermittent Compressive Force on Proteoglycan Content in Calcifying Growth Plate Cartilage in Vitro".
Lanyon et al., J. Biomechanics, vol. 17, No. 12, pp. 897-905, "Static vs Dynamic Loads as an Influence on Bone Remodeling".
R. Buck, "Reorientation Response of Cells Repeated Stretch and Recoil of the Substratum".
S. Takeuchi, Developmental Biology 70, pp. 232-240, "Wound Healing in the Cornea of the Chick Embryo".
Vandenburgh et al., Science, 19 Jan. 1979, vol. 23, pp. 265-268, "In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle".
Leung et al., Experimental Cell Research 109, pp. 285-298, "A New in Vitro System for Studying Cell Response to Mechanical Stimulation".
Beisner William H.
Richman Barry S.
LandOfFree
Method for growing tissue specimens in vitro does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for growing tissue specimens in vitro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for growing tissue specimens in vitro will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1722224