Method for grafting molecules of interest on inorganic...

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Reexamination Certificate

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C427S301000, C427S337000, C438S049000

Reexamination Certificate

active

07919046

ABSTRACT:
The invention concerns a method for grafting molecules of interest on a silicon substrate via a spacer compound, said grafting including at least one click chemistry reaction to the supports thus obtained as well as their uses in nanotechnologies and nanobiotechnologies, such as molecular electronics, the manufacture of biochips or of sensors.

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patent: 2009/0082222 (2009-03-01), Cai et al.
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“A New Bio-active Surface for Protein Immobilization via Copper-free Click” between Azizo SAM and alkynyl Fischer Carbene Complex, Chem. Comm. (2008) p. 5957-5959.
“A Non-oxidative Approach toward Chemically and Electrochemically Functionalizing Si(111)”, JACS (2006), 128, 9518-9525.
Yin, H.B. et al., “Submicron Pattering of DNA Oligonucleotides on Silicon”, Nucleic Acids Research,vol. 32, No. 14, pp. e118 1-e118 7, XP002393285, 2004.
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Sharpless, K.B. et al., “Click Chemistry Olefins, Spring-Loaded Electrophoresis, and Heteroatom Connections Are Key Elements in a Fast, Modular, Process-Driven Approach to Molecular Discovery”, Angewandte Chemie, vol. 40, pp. 2004-2021, XP001206265, 2001.
Rostovtsev et al., “A Stepwise Huisgen Cycloaddition Process: Copper (I)-Catalyzed Regioselective “Litigation” of Azides and Terminal Alkynes”, Angewandte Chemie, vol. 41, No. 14, pp. 2596-2599, XP002331267, 2002.
Tornoe, C. W. et al., “Peptidotriazoles on Solid Phase [1,2,3]-Triazoles by Regiospecific Copper (I) Catalyzed 1, 3-Dipolar Cycloadditions of Terminal Alkynes to Azides”, Journal of Organic Chemistry, vol. 67, No. 9, pp. 3057-3064, XP002234501, 2002.
Alvarez, S.G. et al., “A Practical Procedure for the Synthesis of Alkyl Azides At Ambient Temperature in Dimethyl Sulfoxide in High Purity and Yield” Synthesis, vol. 413, pp. 413-414, XP002394856, 1997.
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