Method for generating replication defective viral vectors...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S456000, C435S235100, C435S320100, C514S04400A

Reexamination Certificate

active

08067156

ABSTRACT:
Sequences are provided that are capable of directing circular adeno-associated virus replication, useful in vectors for providing therapeutic agents to a subject in need thereof. The vectors of the invention are particularly useful in the treatment of acute medical conditions requiring rapid gene expression. Further provided are methods for producing packaged defective viral vectors.

REFERENCES:
patent: 5478745 (1995-12-01), Samulski et al.
patent: 5658724 (1997-08-01), DeLuca
patent: 5869305 (1999-02-01), Samulski et al.
patent: 6221646 (2001-04-01), Dwarki et al.
patent: 6261834 (2001-07-01), Srivastava
patent: 6436392 (2002-08-01), Engelhardt et al.
patent: 6491907 (2002-12-01), Rabinowitz et al.
patent: 6893865 (2005-05-01), Lockert et al.
patent: WO 93/09239 (1993-05-01), None
patent: WO 94/13788 (1994-06-01), None
patent: WO 9506743 (1995-03-01), None
patent: WO 98/09524 (1998-03-01), None
patent: WO 01/25465 (2001-04-01), None
Maxwell et al. An adenovirus type 5 mutant with the preterminal protein gene deleted efficiently provides helper functions for the production of recombinant adeno-associated virus. J Virol. vol. 72, No. 10, pp. 8371-8373, Oct. 1998.
Duan et al. (Virology. 1999; 261:8-14).
Musatov et al. (Journal of Virology. Dec. 2002; 76(24): 12792-12802).
Allen et al., Identification and Elimination of Replication-Competent Adeno-Associated Virus (AAV) That Can Arise by Nonhomologous Recombination during AAV Vector Production, Journal of Virology, vol. 71:6816-6822 (1997).
Lusby et al., Nucleotide Sequence of the Inverted Terminal Repetition in Adeno-Associated Virus DNA, Journal of Virology, vol. 34:402-209 (1980).
Mishra et al., Adeno-associated Virus DNA Replication is Induced by Genes That Are Essential for HSV-1 DNA Synthesis, Virology, vol. 179:632-639 (1990).
Wang et al., Rescue and Replication of Adeno-Associated Virus Type 2 as well as Vector DNA Sequences from Recombinant Plasmids Containing Deletions in the Viral Inverted Terminal Repeats: Selective Encapsidation of Viral Genomes in Progeny Virions, Journal of Virology, vol. 70:1668-1677 (1996).
Wang et al., Adeno-Associated Virus Type 2 DNA Replication in Vivo: Mutation Analyses of the D Sequence in Viral Inverted Terminal Repeats, Journal of Virology, vol. 71:3077-3082 (1997).
Samulski et al., Rescue of Adeno-Associated Virus from Recombinant Plasmids: Gene Correction within the Terminal Repeats of AAV, Cell, vol. 33:135-143 (1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for generating replication defective viral vectors... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for generating replication defective viral vectors..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for generating replication defective viral vectors... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4265782

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.