Method for generating primate trophoblasts

Details Method for generating primate trophoblasts Method for generating primate trophoblasts

2006-12-12

2006-12-12

Nguyen, Dave Trong (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S363000, C435S366000

Reexamination Certificate

active

07148062

ABSTRACT:
The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to transform into human trophoblast cells, the precursor cells of the placenta. Several protein factors including bone morphogenic protein 4 (BMP4), BMP2, BMP7, and growth and differentiation factor 5 can serve as trophoblast-inducting factors.

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