Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se – Higher plant – seedling – plant seed – or plant part
Reexamination Certificate
2005-05-31
2005-05-31
Kruse, David H (Department: 1638)
Multicellular living organisms and unmodified parts thereof and
Plant, seedling, plant seed, or plant part, per se
Higher plant, seedling, plant seed, or plant part
C435S468000, C435S419000, C800S288000
Reexamination Certificate
active
06900370
ABSTRACT:
Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover, methods to inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants.
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Grasso Luigi
Kinzler Ken
Nicolaides Nicholas C.
Sass Phillip M.
Vogelstein Bert
Banner & Witcoff , Ltd.
John Hopkins University
Kruse David H
Morphotek Inc.
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