Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2008-01-15
2008-01-15
Bertoglio, Valarie (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
C435S455000, C435S456000, C435S320100, C435S325000
Reexamination Certificate
active
10873114
ABSTRACT:
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. The enhanced rate of mutation can be further augmented using mutagens. Moreover, the hypermutability of mismatch repair deficient cells can be remedied to stabilize cells or mammals with useful mutations.
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Grasso Luigi
Kinzler Kenneth W.
Nicolaides Nicholas C.
Sass Philip M.
Vogelstein Bert
Bertoglio Valarie
Morphotek Inc.
Shen Wu-Cheng Winston
The Johns Hopkins University School of Medicine
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