Method for generating hypermutable organisms

Details Method for generating hypermutable organisms Method for generating hypermutable organisms

1998-04-14

2000-11-14

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

435455, 435325, C12N 1500

Patent

active

061468940

ABSTRACT:
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation.

REFERENCES:
Glaab WE et al. Carcinogenesis 18:1-8, 1997.
Nicolaides et al Nature 371:75-80, 1994.
Nicolaides NC et al Mol. Cell. Biol. 18:1635-1641, 1998.

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