Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2006-10-17
2006-10-17
Sullivan, Daniel M. (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S326000, C435S377000, C435S441000, C435S455000, C435S029000
Reexamination Certificate
active
07122339
ABSTRACT:
The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing the rate of accumulation of mutations in the V genes and other genes of the selected cells; and c) selecting a cell in which the rate of V gene mutation exceeds that of other gene mutation.
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Cumbers Sarah Jane
Neuberger Michael Samuel
Sale Julian Edward
Edwards Angell Palmer & & Dodge LLP
Medical Research Council
Sullivan Daniel M.
Williams Kathleen M.
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