Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1993-10-20
1998-11-17
Woodward, Michael P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241851, 42419611, 4242291, 4242311, 4242241, 530323, 530326, A61K 3912, A61K 39205, A61K 39245, C07K 14145
Patent
active
058372490
ABSTRACT:
A novel method of presenting an immunogenic peptide to an antigen presenting cell (APC) of a mammalian host, in order to generate a T cell response protective against a virus, such as herpes or rabies virus, comprising administering an immunologically effective amount of (1) a peptide-fatty acid conjugate, the peptide having the amino acid sequence corresponding to the sequence of a fragment of a glycoprotein or protein of the virus which produces a T cell response or a synthetic replica thereof, (2) a liposome composition and (3) an adjuvant so that the peptide protrudes from the liposome and when the liposome fuses with the APC, the peptide remains bound to the cell surface of the APC membrane.
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Dietzschold Bernhard
Heber-Katz Ellen
The Wistar Institute
Woodward Michael P.
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