Method for gene transfer into target cells with retrovirus

Details Method for gene transfer into target cells with retrovirus Method for gene transfer into target cells with retrovirus

2005-09-27

2005-09-27

Parkin, Jeffrey S. (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

06949623

ABSTRACT:
The present invention provides a method for increasing the efficiency of gene transfer into target cells with a retrovirus. The transduction is affected by infecting target cells with a retrovirus in the presence of a mixture of a functional material having a retrovirus binding domain, and a second functional material having target cell binding domain. The target cells may be selected from the group of unintentional hematopoietic progenitor cells and erythrocyte precursor, specifically pluripotent stem cells or embryopalstic stem cells.

REFERENCES:
patent: 5302701 (1994-04-01), Hashi et al.

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