Method for forming controlled release polymeric substrate

Details Method for forming controlled release polymeric substrate Method for forming controlled release polymeric substrate

1993-08-13

1996-01-30

Kim, Kay K. A.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

424484, 424499, 4241841, 514774, 514776, 514773, 530356, 530354, 530409, A61K 3900, A61K 952

Patent

active

054878950

ABSTRACT:
A method for forming a controlled release polymeric substrate is provided by contacting a polymeric substrate with a liquid mixture containing a cross-linking agent at least partially soluble therein comprising water and an organic liquid, for a period of time and at a temperature and concentration of the agent sufficient for the agent to penetrate the substrate to form cross-linking bridges in the substrate in a decreasing concentration gradient beneath the surface.

REFERENCES:
patent: 3427301 (1969-02-01), Needles et al.
patent: 3469003 (1969-09-01), Haver-Lockhart
patent: 4061787 (1977-12-01), Higgins
patent: 4140537 (1979-02-01), Luck et al.
patent: 4233360 (1980-11-01), Luck et al.
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4294241 (1981-10-01), Miyata
patent: 4404033 (1983-09-01), Steffan et al.
patent: 4448718 (1984-05-01), Yannas et al.
patent: 4500453 (1985-02-01), Shank
patent: 4535010 (1985-08-01), Axen et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4590020 (1986-05-01), Itaba et al.
patent: 4597762 (1986-07-01), Walter et al.
patent: 4703108 (1987-10-01), Silver et al.
patent: 4808399 (1989-02-01), Rypacek et al.
patent: 4824620 (1989-04-01), Casa et al.
patent: 4863647 (1989-09-01), Baylor
patent: 4882150 (1989-11-01), Kaufman
patent: 4892700 (1990-01-01), Guerra et al.
patent: 4923699 (1990-05-01), Kaufman
patent: 4923700 (1990-05-01), Kaufman
patent: 4948540 (1990-08-01), Nigam
patent: 4958008 (1990-09-01), Petite et al.
patent: 4969912 (1990-11-01), Kelman et al.
patent: 4970298 (1990-11-01), Silver et al.
patent: 4971954 (1990-11-01), Brodsky et al.
patent: 4981912 (1991-01-01), Kurihara
patent: 5024742 (1991-06-01), Nesburn et al.
Horakova, Z., et al. "Prolongation of Various Pharmacological Effects by Means of Collagen Substances", Therapie, vol. 22, 1967, pp. 1455-1460 and Translation from French.
M. Chvapil, R. Kronenthal, W. van Winkle; Medical and Surgical Applications of Collagen; Int. Rev. Conn. Tissres, 6:1-61 (1973).
M. Dunn, T. Miyata, K. Stenzel, A. Rubin; Studies on Collagen Implants in the Vitreous; Surgical Forum/Ophthalmic Surgery, vol. 19, 492-494 (1968).
A. Rubin, K. Stenzel; Collagen as a Biomaterial; Technology Review, vol. 71, No. 2, 44-49 (1968).
E. Balazs, D. B. Sweeney; A. McPherson (ed.); The Injection of Hyaluronic Acid and Reconstituted Vitreous into the Vitreous Cavity; New and Controversial Aspects of Retinal Detachment, 36:371-376 (1968).
S. Richard-Blum, G. Ville; Minireview: Collagen Crosslinking; Int. J. Biochem., vol. 21, No. 11, 1185-1189 (1989).
M. Chvapil, D. Speer, W. Mora, C. Eskelson; Effect of Tanning Agent on Tissue Reaction to Tissue Implanted Collagen Sponge; Journal of Surgical Research, 35, 402-409 (1983).
K. Weadock, R. Olson, F. Silver; Evaluation of Collagen Crosslinking Techniques; Biomat., Med., Dev., Art. Org., 11 (4), 293-318 (1983-84).

Affiliated with

Also associated with

Rating

Method for forming controlled release polymeric substrate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for forming controlled release polymeric substrate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for forming controlled release polymeric substrate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-155797