Method for forming amphotericin B crystals in fermentation broth

Details Method for forming amphotericin B crystals in fermentation broth Method for forming amphotericin B crystals in fermentation broth

1986-04-16

1988-05-31

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435262, 435276, 435886, 514 31, C12P 1962, C12R 1465

Patent

active

047481170

ABSTRACT:
A new method is provided for forming crystals of amphotericin B directly in fermentation broth which crystals are easily separable without use of costly solvent extraction techniques which method includes a direct microbial cell autolysis step to induce crystal formation.

REFERENCES:
patent: 2908611 (1959-10-01), Ductcher et al.
patent: 2908612 (1959-10-01), Ductcher et al.
patent: 3914409 (1975-10-01), McGahren et al.
patent: 4177265 (1979-12-01), Michel et al.
Merck Index, #611, (1983), p. 85.

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