Method for forestalling the hook effect in a multi-ligand immuno

Details Method for forestalling the hook effect in a multi-ligand immuno Method for forestalling the hook effect in a multi-ligand immuno

1985-04-11

1988-05-10

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436501, 436533, 436534, 436548, 436818, G01N 33546, G01N 33577

Patent

active

047435429

ABSTRACT:
A method is provided for substantially increasing the dynamic range of an immunoassay and forestalling the hook effect observed with very large ligand concentrations in aqueous samples. The method comprises the addition of ligand binding partners which do not have labels associated therewith to compete with labeled ligand binding partners thereby effectively eliminating the presence of the excess ligand in the sample solution. The conversant method for ligand binding partner immunoassays is also provided.

REFERENCES:
patent: 4230797 (1980-10-01), Boguslaski et al.
patent: 4248965 (1981-02-01), Mochida et al.
patent: 4595661 (1986-06-01), Cragle et al.

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