Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues
Patent
1994-02-17
1995-09-05
Willis, Jr., Prince
Bleaching and dyeing; fluid treatment and chemical modification
Treatment of hides, skins, feathers and animal tissues
Internal tissues
8 9433, 530356, 623 1, 623 2, 623 3, 623 11, 523113, A61F 202
Patent
active
054475368
ABSTRACT:
A process is provided for the non-glutaraldehyde fixation of a prosthesis to be implanted in a mammal whereby the prosthesis is fixed by employing cross-linking agents to form amide linkages between and within the molecules of the prosthetic tissue. The disclosed process prevents or retards calcification and results in a product which does not cause inflammation and is nontoxic; it thus provides prostheses that are well-suited for implantation in a mammal.
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Harasaki et al., "Cross-Linking Agents, Degree of Cross-Linking and Calcifiability in Bioprosthetic Heart Valves", Soc. for Biomaterials, 16th Annl. Meeting, p. 25, May 20-23, 1990.
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Girardot Jean-Marie
Girardot Marie-Nadia
Biomedical Design, Inc.
Diamond Alan D.
Willis Jr. Prince
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