Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-10-27
1997-10-21
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, C12Q 168, G01N 3374
Patent
active
056795181
ABSTRACT:
The NER receptor is a novel member of the steroid hormone receptor superfamily and has been prepared by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. The complete sequence of human NER complementary DNA (Seq. ID No. 1), expression systems including a COS stable expression system, the expressed protein (SEQ. ID No. 2) and an assay using the COS expression system are disclosed. The assay may be used to identify agents which activate transcription mediated by the NER receptor, and which are useful for potentiating the activity of a modulator of a G-protein coupled receptor wherein the G-protein coupled receptor is a member of the steroid hormone receptor superfamily.
REFERENCES:
patent: 4981784 (1991-01-01), Evans et al.
patent: 5030576 (1991-07-01), Dull et al.
Shinar et al. Gene 147 (1994) 273-276.
Apfel et al. Mol. Cell. Biol. 14 (1994) 7025-7035.
Arbeeny, "Inhibition of fatty acid synthesis decreases renal low density lipoprotein secretion in the hamster", J. Lipid Res. 33: 843-851 (1992).
Halvorson and McCune, "Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoric acid", Lipids 19(11): 851-856 (1984).
Otto et al., "Reciprocal effects of 5-(tetradecyloxy)-2-fuoric acid on fatty acid oxidation", Arch. Biochem. Biophys. 242(1): 23-31, (1985).
Parker et al., "5-(tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyrylcarboxylic acids" J. Med. Chem. 20: 781-791 (1977).
Olson, "Reparative strategies in brain-treatment strategies based on trophic factors and cell transfer techniques", Acta Neurochirurgica 58: 3-7, 1993.
Seiger et al., "Intercranial infusion of purified nerve growth factor to an alzheimer patient" Behaviorial Brain Research 57: 255-261, 1993.
Power, et al., "Dopamine activation of an orphan of the steroid receptor superfamily", Science 254(5038): 1636-1639, 1991.
Power et al., "New Insights into activation fo the steroid hormone receptor superfamily", Trends Pharmacol. Sci. 13(8): 318-323, 1992.
Power et al., "Dopaminergic and igand-independent activation of steroid hormone receptors", Science 254 (50380; 1636-1639, 1991.
Lomax and Daniel, "Cocaine and body temperature in the rat: effect of dopamine D1 antagonists", Proc. west Pharmacol. Soc. 34: 5-9, 1991.
Witkin et al., "Interaction of halopenidol and SCH23390 with cocaine and dopamine receptor subtype-selective agonists on schedule-controlled behavior of squirrel monkeys", Psychopharmacology Berl. 104(4): 452-431, 1991.
Virno et al., "Dopamine, dopaminergic drugs and ocular hypertension", Int. Ophthalmol 16(4-5) 349-353, 1992.
Boyson and Alexander, "Net Production of cerebrospinal fluid is decreased by SCH22390", Ann. Neurol. 27 (6): 631-635, 1990.
Lee and Kerlavage, "Molecular biology of G-protein-coupled receptors", Drug News Perspec. 6(7): 488-497, 1993.
Stryer and Bourne, "G proteins, a family of signal transducers", Ann. Rev. Cell. Biol. 2: 391-419, 1986.
Chao et al., "Gene Transfer and Molecular Cloning of the Human NGF Receptor" Science 232: 518-521, 1986.
Levi-Montalcini and Calissano, "The Nerve-Growth Factor" Sci. Amer. 240 (6): 68-77, 1979.
Gilman, "G Proteins: Transducers of Receptor-Generated Signals" Ann. Rev. Bichem. 56: 615-49, 1987.
Berg, "DNA Binding Specificity of Steroid Receptors", J.M. Cell, 57: 1065-1068 (1989).
Evans, R.M., "The Steroid an Thyroid Hormone Receptor Superfamily", Science 240: 899-895 (1988).
Beato, "Gene Regulation by Steroid Hormones" M. Cell 56: 335-344 (1989).
Isseman, I. et al., "Activation of a Member of the Steroid Hormone Receptor superfamily by Peroxisome Proliferators", Nature 347: 645-650 (1990).
Mangelsdorf, et al., "Nuclear Receptor that Identifies a Novel Retinoic Acid Response Pathway", Nature 345: 224-229 (1990).
McGurk et al. "Dopominergic Drugs Reverse the Impairment of Radial-Arm Maze Performance Caused by Lesions Involving the Cholinergic Medial Pathway", Neuroscience vol. 50 No. 1 pp. 129-135 (1992).
Friedman Eitan
Holloway M. Katharine
Rodan Gideon A.
Rutledge Su Jane
Schmidt Azriel
Allen Marianne P.
Coppola Joseph A.
Dolan Catherine A.
Hahnemann Univ.
Hayes Robert C.
LandOfFree
Method for finding transcription activators of the NER steroid h does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for finding transcription activators of the NER steroid h, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for finding transcription activators of the NER steroid h will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1005755