Combinatorial chemistry technology: method – library – apparatus – Apparatus specially adapted for use in combinatorial...
Reexamination Certificate
2004-03-19
2011-11-29
Gross, Christopher M (Department: 1636)
Combinatorial chemistry technology: method, library, apparatus
Apparatus specially adapted for use in combinatorial...
C435S004000, C435S006120, C435S007100, C977S742000
Reexamination Certificate
active
08067341
ABSTRACT:
Carbon nanotube (CNT) films, patterns and biochips and methods of making the same are provided. Such a biochip comprises a bio-receptor attached by means of an exposed chemical functional group on a surface of a high density CNT film or pattern produced by repeated lamination of CNTs on a substrate with exposed amine groups. Various types of CNT-biochips may be fabricated by bonding of bio-receptors to a CNT pattern (or film) containing exposed carboxyl groups or modified by various chemical functional groups. Further, the CNT-biochip may be used to measure an electrical or electrochemical signal using both conductor and semiconductor properties of the CNT, thereby not needing labeling. Upon fluorescent measurement of DNA hybridization using such a CNT-DNA chip it is possible to show more distinct signals useful for genotyping, mutation detection, pathogen identification and the like.
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Copending U.S. Appl. No. 10/860,544, filed Jun. 3, 2004.
Jung Dae Hwan
Jung Hee Tae
Kim Byung Hun
Ko Young Koan
Lee Sang Yup
Gross Christopher M
Hultquist Steven J.
Hultquist IP
Reynolds Kelly K.
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