Method for extracting a macrolide from biomatter

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S132000, C435S169000, C435S252100, C435S253500, C435S898000

Reexamination Certificate

active

07432074

ABSTRACT:
Provided is a method for obtaining a macrolide, especially tacrolimus, from biomatter.

REFERENCES:
patent: 3993749 (1976-11-01), Sehgal et al.
patent: 4160861 (1979-07-01), Cole et al.
patent: 4477682 (1984-10-01), Tomita et al.
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5116756 (1992-05-01), Dumont et al.
patent: 5194378 (1993-03-01), Salituro et al.
patent: 5200505 (1993-04-01), Takesako et al.
patent: 5264355 (1993-11-01), Shaifee et al.
patent: 5494820 (1996-02-01), Cullen et al.
patent: 5496727 (1996-03-01), Okuhara et al.
patent: 5506233 (1996-04-01), Hauske et al.
patent: 5508398 (1996-04-01), Gletsos
patent: 5612316 (1997-03-01), Koch
patent: 5616595 (1997-04-01), Chu et al.
patent: 5622866 (1997-04-01), Motamedi et al.
patent: 5624842 (1997-04-01), Okuhara et al.
patent: 6387258 (2002-05-01), Keri et al.
patent: 2002/0010328 (2002-01-01), Reeves et al.
patent: 2002/0128470 (2002-09-01), Fuenfschilling et al.
patent: 2003/0166924 (2003-09-01), Keri et al.
patent: 2004/0050782 (2004-03-01), Fuenfschilling et al.
patent: 692 839 (2002-11-01), None
patent: 2121517 (1972-11-01), None
patent: 0 184 162 (1986-06-01), None
patent: 0 652 219 (1995-05-01), None
patent: 1 234 833 (2002-08-01), None
patent: 2 225 576 (1990-06-01), None
patent: 4128289 (1992-04-01), None
patent: WO 92/18506 (1992-10-01), None
patent: WO 00/33878 (2000-06-01), None
patent: WO-00/71546 (2000-11-01), None
patent: WO-01/18007 (2001-03-01), None
The Merck Index, Maryadele J. O'Neil et al. eds., “Pimecrolimus”, p. 1331, 13th ed. 2001.
Martindale: The complete drug reference, Sean C. Sweetman ed., “Sirolimus”, p. 568, Pharmaceutical Press 33rd ed. 2002.
C.E.M. Griffiths “Ascomycin: An Advance in the Management of Atopic Dermatitis” British J. of Dermatology, V. 144, p. 679-681, (2001).
Martindale: The complete drug reference, Sean C. Sweetman ed., “Everolimus”, p. 539, Pharmaceutical Press 33rd ed. 2002.
Zhiguo Song et al. “Highly Chemoselective Trichloracetimidate-Mediated Alkylation of Ascomycin: A Convergent, Practical Synthesis of the Immunosupporessant L-733,725” J. Org. Chem. 1999, v. 64, p. 1859-1867.
Jun'ichi Kobayashi et al. “Amphidinolides T2, T3, and T4, New 19-Membered Macrolides from the Dinoflagellate Amphidinium sp. and the Biosynthesis of Amphidinolide T1” J. Org. Chem. 2001, v. 66, p. 134-142.
K. Yoshii et al. “Liquid Chromatographic Determination of Emamectin, Milbemectin, Ivermectin and Abamectin in Crops and Confirmation by Liquid Chromatography—Mass Spectrometry” Journal of Chromatography A, v. 896, 2000, p. 75-85.
Patent Abstract of Japan Publication No. 02016662; Publication date Jan. 19, 1990; Akashi Kazuya “Substituting Terminal Controller”.
Surjit S. Sengha, Fermentation, in Kirk Othmer Encyclopedia of Chemical Technology, vol. 10, p. 361-381 (Jacquiline I. Kroschwitz, editor. 4th ed. 1993).
Aceto Pharma GmbH letter to European Patent Office, “‘Observations by Third Party’ in accordance with Art. 115 EPC regarding European patent application No. 03709066.9”, Aug. 27, 2004.
Arndt, Cristl, et al., “Secretion of FK506/FK520 and rapamycin byStreptomycesinhibits the growth of competingSaccharomyces cerevisiaeandCryptococcus neoformans”, Microbiology, 1999, vol. 145, pp. 1989-2000.
Akashi, Takeshi, et al., “Quantitative determination of tautomeric FK506 by reversed-phase liquid chromatography”, Journal of Pharmaceutical and Biomedical Analysis, 1996, vol. 14, pp. 339-346.
Volosov, Andrew, et al., “Simultaneous simple and fast quantification of three major immunosuppressants by liquid chromatography—tandem mass-spectrometry”, Clinical Biochemistry, 2001, vol. 34, pp. 285-290.
Venkataramanan, Raman, et al., “Clinical Utility of Monitoring Tacrolimus Blood Concentrations in Liver Transplant Patients”, Journal of Clinical Pharmacology, 2001, vol. 41, pp. 542-551.
Motamedi, Haideh, et al., “Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506”, European Journal of Biochemistry, Feb. 1997, vol. 244, No. 1, pp. 74-80.
Motamedi, Haideh, et al., “The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506”, European Journal of Biochemistry, 1998, vol. 256, pp. 528-5343.
Aichi, Ken, et a., “Studies on the Development of Tacrolimus Production”, Seibutsu Kogaku Kaishi, 1998, vol. 76, No. 9, pp. 389-397.
Shafiee, Ali, et al., “Enzymology of FK506 biosynthesis: Purification and characterization of 31-O-desmethylFK-506 O: methyltransferase fromStreptomycessp. MA6858”, European Journal of Biochemistry, Oct. 1994, vo. 225, No. 2, pp. 755-764.
Motamedi, Haideh, et al., “Characterization of Methyltransferase and Hydroxylase Genes Involved in the Biosynthesis of the Immunosuppressants FK506 and FK520”, Journal of Bacteriology, Sep. 1996, vol. 178, No. 17, pp. 5243-5248.
Schwecke, Torsten, et al., “The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin”, Proc. Natl. Acad. Sci. USA, Aug. 1995, vol. 95, pp. 7839-7843.
Wu, Kai, et al., “The FK520 gene cluster ofStreptomyces hygroscopicusvar.ascomyceticus(ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units”, Gene, 2000, vol. 251, pp. 81-90.
Kino, Toru, et al., “FK-506, A novel Immunosuppressant Isolated From AStreptomyces: I. Fermentation, Isolation, and Physico-Chemical and Biological Characteristics”, The Journal of Antibiotics, vol. XL, No. 9, pp. 1249-1255.
Yoon, Yeo Joon, et al., “Nutrient Effects on FK-506, a New Immunosuppressant, Production byStreptomycessp. in a Defined Medium”, Journal of Fermentation and Bioengineering, 1997, vol. 83, No. 6, pp. 599-603.
Takeuchi, Miwako, et al., “Ring-closing metathesis protocol for a diastereocontrolled preparation of the C28-C34segment of FK-506”, Tetrahedron: Asymmetry, 2000, vol. 11, pp. 1601-1606.
Namyslo, Jan-Christoph, et al., “An Aldol Approach to a Building Block corresponding to the C21-C26-Part of FK506”, J. Prakt. Chem., 1999, vol. 341, No. 6, pp. 557-561.
Baker, Robert K., et al., “Synthetic Studies on the Immunosuppressive Agent FK-506: Enantioselective Synthesis of a C22-C34 Fragment”, Tetrahedron Letters, 1998, vol. 39, pp. 229-232.
Morimoto, Yoshiki, et al., “A Synthesis of C1-C22 Fragment of the Immunosuppressant FK506. Stereoselective Construction of (E)-Trisubstituted Double Bond (C19-C20) via Ester-enolate Claisen Rearrangement”, Tetrahedron Letters, 1991, vol. 32, No. 25, pp. 2909-2912.
Marshall, James A., et al., “Synthesis of a C22-34 Subunit of the Immunosuppressant FK-506”, Journal of Organic Chemistry, 1996, vol. 60, pp. 7230-7237.
Ireland, Robert E., et al., “A Total Synthesis of FK-506”, Journal of Organic Chemistry, 1996, vol. 61, pp. 6856-6872.
Ireland, Robert E., et al., “Total Synthesis of FK-506. Part 1: Construction of the C16-C34 Fragment”, Tetrahedron, 1997, vol. 53, No. 39, pp. 13221-13256.
Ireland, Robert E., et al., “Total Synthesis of FK-506. Part 2. Completion of the Synthesis”, Tetrahedron, 1997, vol. 53, No. 39, pp. 13257-13284.
Smith, Amos B., et al., “Formal Total Synthesis of FK506. Concise Consttruction of the C(10)-C(34) Segment Via an Effective Coupling Tactic”, Tetrahedron Letters, 1994, vol. 35, No. 25, pp. 4271-4274.
Nakatsuka, Masashi, et al., “Total Synthesis of FK506 and an FKBP Probe Reagent, (C8, C9-13C2)-FK506”, Journal of the American Chemical Society, 1990, vol. 112, pp. 5583-5601.
Jones, Todd K., et al., “Total Synthesis of the Immunosuppressant (−)-FK-506”, Journal of the American Chemical Society, 1989, vol. 111, pp. 1157-1159.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for extracting a macrolide from biomatter does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for extracting a macrolide from biomatter, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for extracting a macrolide from biomatter will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4016622

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.