Method for extending the useful shelf-life of refrigerated red b

Details Method for extending the useful shelf-life of refrigerated red b Method for extending the useful shelf-life of refrigerated red b

1995-06-05

1997-04-29

Rollins, John W.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

604 4, A01N 102, A61M 3700

Patent

active

056247940

ABSTRACT:
Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

REFERENCES:
patent: 4902701 (1990-02-01), Batchelor et al.
patent: 5476764 (1995-12-01), Bitensky
Hogman CF et al, Biomed. Biochim. Acta 42:S327-331 (1983).
Hogman CF et al., Biomed. Biochim Acta 46:S290-294 (1987).
T.J. Greenwalt et al., "Studies In Red Blood Cell Preservation-7. In Vivo and in Vitro Studies With A Modified Phosphate-Ammonium Additive Solution," Vox Sang 65, 87-94 (1993).
E. Beutler et al., "Storage Of Red Cell Concentrates In CPD-A2 For 42 and 49 Days," J. Lab. Clin. Med. 102, pp. 53-62 (1983).
Hogman et al., "Effects Of Oxygen On Red Cells During Liquid Storage at +4.degree.C," Vox Sang, 51, 27-34 (1986).

Affiliated with

Also associated with

Rating

Method for extending the useful shelf-life of refrigerated red b does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for extending the useful shelf-life of refrigerated red b, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for extending the useful shelf-life of refrigerated red b will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-704797