Method for extending storage of glutathione solutions and...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Containing at least one abnormal peptide link – e.g. – gamma...

Reexamination Certificate

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C514S002600, C514S018700, C514S021800, C062S060000, C062S062000

Reexamination Certificate

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07449546

ABSTRACT:
A method of storing solutions of reduced glutathione for extended periods of time, by dissolving reduced glutathione in an aqueous medium having a pH of between 5.0 and 8.0 to produce a reduced glutathione solution; reducing the temperature of the reduced glutathione solution to a predetermined temperature which is sufficiently low to prevent oxidative dimerization of glutathione without freezing the aqueous medium; and storing the reduced glutathione solution at the predetermined temperature.

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Samii et al. Parkinson's Disease; The Lancet, vol. 363, May 29, 2004, pp. 1783-1793.
Kikkawa, et al., Change Due to Aging of Potassium Content, Carbonic Anhydrase, and Hemolysis of the Cold-Stored Human Erythrocyte, and Effect of Some Glucides, Thiol Compounds, and Adenosine-Triphosphate on Them, Jap. J. Pharmocology, (1959) 9, pp. 24-29.
G. Sechi; Reduced intravenous glutathione in the treatment of early parkinson's disease; Prog. In Neuro-Psychopharmacol. and Biol. Psychiat, 1996, vol. 20, pp. 1159-1170.

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