Method for extended storage of viable and pathogen-safe...

Details Method for extended storage of viable and pathogen-safe... Method for extended storage of viable and pathogen-safe...

2008-01-29

2008-01-29

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

active

07323295

ABSTRACT:
A method for inhibiting bacterial growth in whole blood and/or blood components, which may therefore also be used to extend the storage time for the whole blood and/or blood components, through treatment with carbon monoxide. This method is preferably used for the preservation of platelets, which are both particularly vulnerable to bacterial and other microbial infection, and which are also particularly suitable for use with the method of the present invention. Carbon monoxide may be present in an amount of from about 40% to about 100%. Platelets may be stored in a solution buffered by any suitable buffer, such as sodium bicarbonate. Platelet viability may be determined by measuring the ability to aggregate, for example in response to an agonist such as collagen.

REFERENCES:
patent: 5476764 (1995-12-01), Bitensky
Amersi et al., “Ex Vivo Exposure to Carbon Monoxide Prevents Hepatic Ischemia/Reperfusion Injury Through p38 MAP Kinase Pathway”, Hepatology 35 (4) : 815-823 (2002).
Brune et al., “Inhibition of Platelet Aggregation by Carbon Monoxide is Mediated by Activation of Guanylate Cyclase”, Molecular Pharmacology 32 : 497-504 (1987).

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