Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-01-31
1992-09-29
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C12P 2102
Patent
active
051513498
ABSTRACT:
Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
REFERENCES:
Nakamura et al., EMBO 1:771-775 (1982).
Nakazato Hiroshi
Tanaka Shoji
Tsujimoto Masafumi
Tsuruoka Nobuo
Wada Yayoi
Le Guyader John
Schwartz Richard A.
Suntory Limited
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