Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1984-02-22
1986-01-14
Rosen, Sam
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
A61K 4900, C01N 3348
Patent
active
045645175
ABSTRACT:
Non-human animal subjects are inoculated in utero with a preparation consisting essentially of plasma membrane derived from human neoplasma cells and, after birth, further inoculated with a preparation comprising human neoplasma cells. In this manner, the animal subjects are induced to bear a solid tumor which biologically closely simulates the solid tumor in humans, and thus serve as models for evaluating the therapeutic and/or prophylactic effect on solid tumors in humans of various surgical procedures, immunomodulators, chemotherapeutic agents and the like. In particular, the process of the invention can be applied to study of human solid neoplasms such as osteosarcoma, fibrosarcoma, pancreatic adenosarcoma and the like.
REFERENCES:
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Fudenberg Herman H.
Tsang Kwong Y.
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