Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1984-01-30
1985-02-12
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 29, C12Q 104, C12Q 129
Patent
active
044991878
ABSTRACT:
A method is provided for rapidly and reliably determining the potential carcinogenic activity of hydrocarbon mixtures which is especially useful for those of petroleum origin. A sample of the mixture is extracted with dimethylsulfoxide (DMSO). An inoculum of Salmonella typhimurium tester strain T98 is incubated in the presence of an aliquot of the extract together with an optimal amount of induced rat liver homogenate S9. The excessive production of revertant colonies is a measure of the mutagenic activity of the oil, and this measure is shown to correlate with dermal carcinogenic activity.
REFERENCES:
patent: 4256832 (1981-03-01), Findl et al.
patent: 4299915 (1981-11-01), Thilly et al.
Blackburn Gary R.
Mackerer Carl R.
Schreiner Ceinwen A.
Gilman Michael G.
McKillop Alexander J.
Mobil Oil Corporation
Rosen Sam
Santini Dennis P.
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