Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1987-02-24
1990-07-24
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 29, 435 34, 435 32, 435879, 436 64, C12Q 168, C12Q 102, C12Q 118
Patent
active
049435213
ABSTRACT:
A method for rapidly and reliably determining the potential carcinogenic activity of hydrocarbon mixtures which is especially useful for those of petroleum origin. A sample of the mixture is nitrated under conditions effective to convert the polynuclear aromatic hydrocarbons to their nitrated derivatives, and without separation of the nitrated components, the product is incubated with an inoculum of Salmonella typhimurium tester strain T98. The excessive production of revertant colonies is a measure of the mutagenic activity of the oil, and this measure is shown to correlate with dermal carcinogenic activity.
REFERENCES:
patent: 4499187 (1985-02-01), Blackburn et al.
Prival, M. J., "The Salmonella Mutagenicity Assay, Promises and Problems", in Cellular Systems for Toxicity Testing (Williams, G. M. et al.), the New York Academy of Sciences, New York, N.Y., pp. 154-163 (1983).
Campbell et al., "Nitrated Polycyclic Aromatic . . . ", Carcinogenesis, vol. 2, No. 6, 559-565 (1981).
DiPaolo et al., "Nitration of Carcinogenic . . . ", Carcinogenesis, vol. 4, No. 3, pp. 357-359 (1983).
Rosenkrautz et al., "Mutagenicity . . . ", Mutation Research, 114 (1983), pp. 217-219 (1983).
Tokiwa et al., "1-6 Dinitropyrene: Mutagenicity . . . ", JNCl, vol. 73, No. 6, Dec. 1984, pp. 1359-1363 (1984).
Blackburn Gary R.
Mackerer Carl R.
Schreiner Ceinwen A.
Kepplinger Esther M.
McKillop Alexander J.
Mobil Oil Corporation
Scheiner Toni R.
Speciale Charles J.
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