Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1994-02-04
1995-11-28
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
4241841, 424 91, 435 71, 800 2, 800DIG1, 935111, A61K 4900, A61K 3900, C12N 1500
Patent
active
054705606
ABSTRACT:
Biological effects of agents for diagnostic or therapeutic use are evaluated by administration of the agents to transgenic animals which are transformed with heterologous DNA and which are immune tolerant to the expression product of the heterologous DNA. In a further embodiment, preparations that are immunogenic in the transgenic animal model are purified by reverse immunoaffinity chromatography on antibody obtained from responding transgenic animals.
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Chambers Jasemine C.
Genentech Inc.
Kubinec Jeffrey S.
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