Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Patent
1998-08-12
1999-11-23
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
435 4, 435 29, 435176, 435177, 435968, 435963, 435370, 435366, 424 92, C12Q 126, C12Q 100, C12Q 102
Patent
active
059898445
ABSTRACT:
This invention relates to a method for evaluating the susceptibility of pharmaceutical drugs to metabolism by a specific cytochrome P-450 isozyme, which comprises contacting the sample compound with a reagent composition prepared by adding the specific cytochrome P-450 isozyme to liver microsomes lacking said specific cytochrome P-450 isozyme in a carrier material. More particularly, this invention relates to a useful in vitro quantitative assay for drug metabolism by P-450 isozymes such as CYP2D6, CYP2C19, and CYP2A6. This invention also relates to a reagent composition which is useful for said in vitro assay.
REFERENCES:
patent: 5240831 (1993-08-01), Barnes
patent: 5478723 (1995-12-01), Parkinson et al.
patent: 5525482 (1996-06-01), States et al.
Mizutani Mayumi
Naganeo Fumiharu
Shimada Kaoru
Benson Gregg C.
Leary Louise N.
Pfizer Inc.
Richardson Peter C.
Sheyka Robert F.
LandOfFree
Method for evaluating drug metabolism and reagent compositions t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for evaluating drug metabolism and reagent compositions t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for evaluating drug metabolism and reagent compositions t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1220352