Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1995-06-01
1997-09-23
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424 91, 4241841, 4241851, 435 71, 4351723, 800 2, 800DIG1, 935111, A61K 4900, A61K 3900, C12N 1500
Patent
active
056701349
ABSTRACT:
Biological effects of agents for diagnostic or therapeutic use are evaluated by administration of the agents to transgenic animals which are transformed with heterologous DNA and which are immune tolerant to the expression product of the heterologous DNA. In a further embodiment, preparations that are immunogenic in the transgenic animal model are purified by reverse immunoaffinity chromatography on antibody obtained from responding transgenic animals.
REFERENCES:
Kappel et al., Curr. Opin. in Biotech. 3 : 548-553 (1992).
Shamay et al., Transg. Res. 1 : 124-132 (1992).
Burdon et al., Mech. of Devel. 36 : 67-74 (1991).
Hammer, "Genetic Engineering of Mammalian Embryos" J. Anim. Sci. 63:269-278 (1986).
Pursel et al., "Progress on Gene Transfer in Farm Animals" Veterinary Immunology and Immunopathology 17:303-312 (1987).
Simons et al., "Alteration of the Quality of Milk by Expression of Sheep .beta.-lactoglobulin in Transgenic Mice" Nature 328:530-532 (1987).
Simons et al., "Transgenic Livestock" J. Reprod. Fert. Suppl. 34:237-250 (1987).
Wagner et al., "Genetic Engineering of Laboratory and Livestock Mammals" J. Animal Science 61:25-37 (1985).
Chambers Jasemine C.
Genentech Inc.
Kubinec Jeffrey S.
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