Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1992-03-13
1995-05-16
Elliott, George C.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4352404, 435243, 4351723, 424450, 514 2, 514 44, C12N 504, C12N 506, C12N 1509, A61K 3702
Patent
active
054160162
ABSTRACT:
A method is provided for enhancing transmembrane transport of exogenous molecules. The method comprises contacting a membrane of a living cell with a complex formed between said molecules and ligands selected from biotin, biotin analogs and other biotin receptor-binding ligands, and/or folic acid, folate analogs and other folate receptor-binding ligands to initiate receptor mediated transmembrane transport of the ligand complex. The method is used for the efficient delivery of peptides, proteins, nucleic acids and other compounds capable of modifying cell function into plant, animal, yeast, and bacterial cells.
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Heinstein Peter F.
Horn Mark A.
Low Philip S.
Elliott George C.
Purdue Research Foundation
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