Method for enhancing the safety of metal-ligand chelates as magn

Details Method for enhancing the safety of metal-ligand chelates as magn Method for enhancing the safety of metal-ligand chelates as magn

1989-06-22

1992-01-21

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 4, 436173, 436806, 514492, 514836, 514974, G01N 3100, G01N 2400, A61K 3128

Patent

active

050826492

ABSTRACT:
Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as magnetic resonance imaging contrast agents are more toxic acutely when injected in high concentration or at rapid rates. The use of effective amounts of calcium in the form of, calcium chloride, calcium gluconate, or balanced salt solutions substantially reduces this toxicity without the need to add additional ligand.

REFERENCES:
patent: 4478816 (1984-10-01), Ledley et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4822594 (1989-04-01), Gibby

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