Method for enhancing the lowering of plasma cholesterol levels

Details Method for enhancing the lowering of plasma cholesterol levels Method for enhancing the lowering of plasma cholesterol levels

1988-11-21

1991-03-05

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

514460, A61K 924

Patent

active

049976583

ABSTRACT:
The instant invention is directed to a method for enhancing the lowering of plasma cholesterol level in a subject in need thereof which comprises the time-controlled administration of a nontoxic therapeutically effective amount of an HMG-CoA reductase inhibitor to said subject which surprisingly affords an equivalent or improved reduction of plasma cholesterol levels while significantly reducing the amount of HMG-CoA reductase inhibitor circulating in the bloodstream of the subject as compared to the same parameters when the oral administration of a conventional rapid release dosage form is utilized.

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