Method for enhancing the detection of contamination in a...

Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...

Reexamination Certificate

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C435S029000

Reexamination Certificate

active

08048620

ABSTRACT:
A method for preventing bacterial biofilm formation in a blood product, the method comprising modifying a blood product with a polymer selected from the group consisting of polyethylene glycol (PEG), PEG derivatives and mixtures thereof. Preventing bacterial biofilm formation in this way increases the planktonic to adherent ratio of any contaminating bacteria, and thereby facilitates detection of bacterial contamination.

REFERENCES:
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patent: 2008/0193430 (2008-08-01), Scott et al.
patent: 1 808 695 (2007-07-01), None
patent: WO97/28254 (1997-08-01), None
patent: WO 99/00145 (1999-01-01), None
patent: WO2008/100666 (2008-08-01), None
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Sigma Catalog, p. 652, 2000.
Bradley, A. J., et al., Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes: size does matter.Biochimica et Biophysica Acta. vol. 1561, No. 2 pp. 147-158 (2002).
Park, K.D., et al., Bacterial adhesion on PEG modified polyurethane surfaces.Biomaterials. vol. 19, No. 7-9 pp. 851-859 (1998).
Partial European Search Report corresponding to European Application No. EP 07 25 5004 dated May 7, 2008.
Scott, M. D., et al., Beyond the red cell: pegylation of other blood cells and tissues.Transfusion Clinique et Biologique. vol. 11, No. 1 pp. 40-46 (2004).
AABB Technical Manual, 12thedition, Chapter 7, American Association of Blood Banks, pp. 135-157 (2002).

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