Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-05
1998-03-31
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 424 9371, 530350, 530351, A61K 3900, A01N 6300, C07K 100, C07K 1400
Patent
active
057335508
ABSTRACT:
The present invention provides a method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells to thereby sensitize the target cells for class I MHC-restricted cytotoxic T cell response. The method involves obtaining the peptides of interest and presenting the peptides to the appropriate antigen presenting cells in the presence of an elevated level of free .beta..sub.2 -microglobulin.
The method of the present invention can also be used to prime naive populations of T lymphocytes for antigen-specific class I MHC-restricted cytotoxic T cell response with exogenous peptide and is useful in both in vitro and in vivo applications. A new use for purified .beta..sub.2 -microglobulin as an adjuvant for synthetic peptide vaccines is also provided.
REFERENCES:
Anderson et al, Studies on the Cytophilic Properties of Human .beta..sub.2 Microglobulin, The Journal of Immunology, vol. 114: 997-1000 (Mar. 1975).
Bernabeu et al, .beta..sub.2 -Microglobulin from serum associates with MHC class I antigens on the surface of cultured cells, Nature, vol. 308: 642-645 (Apr. 12, 1984).
Bevan, Michael J., Class discrimination in the world of immunology, Nature, vol. 325: 192-194 (Jan. 15, 1987).
Bevan, Michael J., Stimulating killer cells, Nature, vol. 342: 478-479, (Nov. 30, 1989).
Braciale et al, Antigen Presentation Pathways to Class I and Class II MHC-Restricted T Lymphocytes, Immunological Reviews, No. 98: 95-114 (1987).
Carbone et al, Induction of Cytotoxic T Lymphocytes by Primary In Vitro Stimulation With Peptides, J. Exp. Med., vol. 167: 1767-1779, (Jun., 1988).
Carbone and Bevan, Induction of Ovalbumin-Specific Cytotoxic T Cells By In Vivo Peptide Immunization, J. Exp. Med., vol. 169: 603-612, (Mar. 1989).
Deres et al, In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine, Nature, vol. 342: 561-564 (Nov. 30, 1989).
Germain, Ronald N., The ins and outs of antigen processing and presentation, Nature, vol. 322: 687 (Aug. 1986).
Hyafil and Strominger, Dissociation and exchange of the .beta..sub.2 -microglobulin subunit of HLA-A and HLA-B antigens, Proc. Natl. Acad. Sci. USA, vol. 76: 5834-5838 (Nov. 1979).
Kefford et al, Serum .beta..sub.2 -microglobulin binds to a T-cell differentiation antigen and increases its expressing, Nature, vol. 308: 641-642 (Apr. 12, 1984).
Maryanski et al, H-2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide, Nature, vol. 324: 578-579 (Dec. 11, 1986).
Moore et al, Introduction of Soluble Protein into the Class I Pathway of Antigen Processing and Presentation, Cell, vol. 54: 777-785 (Sep. 9, 1988).
Perkins et al, Identical Peptides Recognized By MHC Class I-and II-Restricted T Cells, J. Exp. Med., vol. 170: 279-289 (Jul. 1989).
Tevethia et al, Biology of Simian Virus 40 (SV40) Transplantation Antigen (TrAg), Virology, vol. 107: 13-23 (1980).
Townsend et al, Association of class I major histocompatibility heavy and light chains induced by viral peptides, Nature, vol. 340: 443-448 (Aug. 10, 1989).
Townsend et al, Cytotoxic T Cells Recognize Fragments of the Influenza Nucleoprotein, Cell, vol. 42: 457-467 (Sep. 1985).
Townsend et al, The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides, Cell, vol. 44: 959-968 (Mar. 28, 1986).
Watari et al, A Synthetic Peptide Induces Long-Term Protection From Lethal Infection With Herpes Simplex Virus 2, J. Exp. Med., vol. 165: 459-470 (Feb. 1987).
Wraith and Askonas, Induction of Influenza A Virus Cross-reactive Cytotoxic T Cells by a Nucleoprotein/Hemagglutinin Preparation, J. Gen. Virol., vol. 66: 1327-1331 (1985).
Yamada et al, Influenza Virus Hemagglutinin-Specific Cytotoxic T Cell Response Induced By Polypeptide Produced in Escherichi coli, J. Exp. Med., vol. 162: 663-674 (Aug. 1985).
Yawdell et al, Cells process exogenous proteins for recognition by cytotoxic T lymphocytes, Science, vol. 239: 637-40 (1988).
Kefford et al, Serum .beta..sub.2 -M binds to a T-cell differentiation antigen and increases its expression, Nature, vol. 308: 641-642 (1984).
Rock et al, Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides 87(19):7517-7521 (Oct., 1990).
Rock et al, Reassociation with .beta.-microglobulin is necessary for D.sub.b class I major hisotcompatibility complex binding of an exogenous influenza peptide, Proc. Natl. Acad. Sci. USA, vol. 88: 301-304 (1991).
Vitiello et al, The Role of .beta..sub.2 -Microglobulin in Peptide Binding by Class I Molecules, Science, vol. 250: 1423-1426 (Dec. 1990).
Koslowski et al, Excess .beta..sub.2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules, Nature, vol. 349: 74-77 (Jan. 1991).
Chen & Parham, Direct binding of influenza peptides to class I HLA molecules, Nature, vol. 337: 743-745 (Feb. 23, 1989).
Benjamin et al, Peptide binding to empty HLA-B27 molecules of viable human cells, Nature, vol. 351: 74-77 (May 2, 1991).
Luescher et al, Specific binding of antigenic peptides to cell-associated MHC class I molecules, Nature, vol. 351: 72-74 (May 2, 1991).
Luescher et al, Interaction Of Antigenic Peptides with MHC Class I Molecules on Living Cells Studied by Photoaffinity Labeling, Journal of Immunology, vol. 148: 1003-1011 No. 4., (Feb. 15, 1992).
Bjorkman et al, The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens, Nature, vol. 329: 512-518 (Oct. 8, 1987).
Bastin et al, Use of Synthetic Peptides of Influenza Nucleoprotein to Define Epitopes Recognized by Class I-Restricted Cytotoxic T Lymphocytes, J. Exp. Med., vol. 165: 1508-1521 (Jun. 1987).
Maryanski et al, Synthetic Peptides As Antigens and Competitors in Recognition by H-2-Restricted Cytolytic T Cells Specific For HLA, J. Exp. Med., vol. 167: 1391-1405 (Apr. 1988).
Yewdell and Bennink, The Binary Logic of Antigen Processing and Presentation to T Cells, Cell, vol. 62: 203-206 (Jul. 27, 1990).
Schumacher et al, Direct Binding of Peptide to Empty MHC Class I Molecules on Intact Cells and In Vitro, Cell, vol. 62: 563-567 (Aug. 10, 1990).
Yewdell and Bennink, Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes, Science, vol. 244: 1072-1075 (Jun. 2, 1989).
Braciale et al, Antigen Presentation Pathways to Class I and Class II MHC-Restricted T, Immunological Reviews, No. 98: 104-108 (1987).
Dana-Farber Cancer Institute Inc.
Hart Julia D.
Smith Lynette F.
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