Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2009-04-15
2011-10-04
Kim, Alexander (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S070100, C530S387100
Reexamination Certificate
active
08030027
ABSTRACT:
The present invention is a method for enhancing recombinant antibody production by co-expressing in a host cell a recombinant antibody and ERp23 protein, which facilitates oxidative folding and stability of the recombinant antibody thereby enhancing production.
REFERENCES:
Miller et al., Expression ofBorrelia burgdorferierp genes during infection of non-human primates, Microbial Pathogenesis, 2005, vol. 39, pp. 27-33.
Meunier al., A Subset of Chaperones and Folding Enzymes Form Multiprotein Complexes in Endoplasmic Reticulum to Bind Nascent Proteins, Molecular Biology of the Cell, vol. 13, pp. 4456-4469.
Shimizu et al., pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin, PNAS, vol. 106, pp. 17013-17018.
Anken et al., Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1, PNAS, vol. 106, pp. 17019-17024.
Katoh et al., “MGC29506gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues”, International Journal of Oncology 2003 23:235-241.
Hendershot Linda M.
Shimizu Yuichiro
Kim Alexander
Licata & Tyrrell P.C.
St. Jude Children's Research Hospital
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